ICSI with testicular sperm for couples with sperm DNA damage
نویسندگان
چکیده
منابع مشابه
Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa.
BACKGROUND Sperm DNA damage (fragmentation) is a recently discovered cause of male infertility for which no efficient treatment has yet been found. Previous findings have suggested that clinically relevant sperm DNA damage may occur at the post-testicular level. This study was undertaken to assess the clinical usefulness of ICSI with testicular spermatozoa in this indication. METHODS The perc...
متن کاملSperm DNA damage and its role in IVF and ICSI
While the semen analysis has traditionally been relied upon to differentiate fertile and infertile men, its utility has been questioned in the current era of assisted reproductive technologies. The desire for more sophisticated diagnostic and predictive tools has led to increased use of sperm DNA damage in the management of male infertility. Despite the availability of numerous assays to measur...
متن کاملEffect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI.
The aim of this study was to evaluate the effect of sperm DNA damage and protamine deficiency on fertilization and embryo development post-intracytoplasmic sperm injection (ICSI), and also to assess the effect of protamine deficiency on DNA damage. Semen samples were collected from 28 patients participating in the ICSI programme. Following sperm preparation and ICSI, the remaining processed sem...
متن کاملUsing Fresh and Frozen Testicular Sperm Samples in Couples Undergoing ICSI-MicroTESE Treatment
BACKGROUND We performed this study to evaluate use of fresh and frozen sperm samples in non-obstructive azoospermia microdissection testicular sperm extraction (micro-TESE-ICSI) treatment. METHODS We performed a total of 82 consecutive in vitro fertilization (IVF) cycles at Fertijin IVF Center in Istanbul, Turkey from January 2010 to March 2012. In 43 participants we used fresh sperm and froz...
متن کاملSperm DNA damage and its relation with leukocyte DNA damage.
DNA fragmentation in human sperm has been related to endogenous and exogenous factors. Exogenous factors can also affect leukocyte DNA integrity. This study evaluated the relation between sperm DNA damage and leukocyte DNA integrity, as a predictor of exogenous factors. DNA damage in the sperm and leukocytes of 41 individuals undergoing ICSI were measured by Comet assay. In addition, sperm chro...
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ژورنال
عنوان ژورنال: International braz j urol
سال: 2018
ISSN: 1677-6119,1677-5538
DOI: 10.1590/s1677-5538.ibju.2018.04.02